The Los Angeles Dodgers (58-42) will host the Minnesota Twins (48-51), Monday at 10:10 p.m. ET, in the first game of a three-game series. The Dodgers are favored (-216 on the moneyline to win) when they host the Twins (+179). The starting pitchers are Shohei Ohtani for the Los Angeles Dodgers, and David Festa (3-3) for the Minnesota Twins.

SportsLine's proven model has simulated Los Angeles Dodgers vs. San Francisco Giants 10,000 times and released its MLB picks for Sunday's game at Oracle Park in San Francisco

Yoshinobu Yamamoto starts Game 1 for the Dodgers. Ron Chenoy-Imagn Images Los Angeles will counter with Yoshinobu Yamamoto, and the Dodgers lost both of his starts against the Padres this season.

The Brewers have been playing great baseball, but expecting them to sweep the Dodgers twice in one month is too much (L.A. is 33-19 at home). Will Smith has destroyed left-handed pitching (179 wRC+), and Shohei Ohtani has been adept at punishing pitchers of either hand, so both are likely to play a part if the Dodgers score runs in bunches.

Pregame analysis and predictions of the Minnesota Twins vs. Los Angeles Dodgers MLB game to be played on July 21, 2025 on ESPN.