Houston started its March Madness run with a victory over SIUE. The real challenge began in the next round, and the Cougars got a fight from eight-seed Gonzaga. The Bulldogs aren't your typical eight-seed, and they almost knocked off Houston.

The SportsLine Projection Model has revealed its Alabama Crimson Tide vs. Duke Blue Devils picks for the Elite Eight of the 2025 NCAA Tournament on Saturday

Experts Calvin Wetzel and Aaron Barzilai have revealed their picks for Duke vs. South Carolina in the Elite Eight of the 2025 Women's NCAA Tournament on Sunday

SportsLine's top college basketball experts reveal their 2025 NCAA Tournament Final Four score predictions, national semifinal picks for Houston vs. Duke and Auburn vs. Florida

Madness NCAA Tournament Final Four score picks, predictions for Auburn vs Florida, Houston vs Duke Saturday. Who will advance to championship?

With only four teams remaining, Duke has the best odds to win the men's national championship at +100. Florida, Auburn and Houston have also made it to San Antonio for the final weekend of March Madness.

Top seeds Duke, Florida, Houston and Auburn saw minimal movement atop the title odds during dominant postseason runs. Despite this year’s Elite Eight teams tying with the 2007 tourney for the lowest combined seed total (13) in tournament history, the four No. 1 seeds demolished four quality opponents by an average of 12.5 points.

Analyzing Saturday’s Alabama vs. Duke odds and lines, with college basketball expert picks, predictions and best bets.

Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.