Detroit swept Green Bay last season, but the early betting lines have the Lions as a slight underdog for Week 1. Using the lines from Draftkings, the Lions are a 1.5-point underdog at Lambeau, a place they won 24-14 in Week 9 in 2024.

The season-opening matchup against Dan Campbell and the Lions kicks off a 2025 schedule that might feature the first bout with one of the best players in franchise history, a daunting home slate, six stand-alone games, a Week 5 bye, a playoff rematch and, probably much to LaFleur’s delight, no international games.