Intra-arterial injection. Premature infants. Risks from concomitant use with opioids; see Interactions. Monitor for respiratory depression and level of sedation; ensure availability of ...

Notably, a single injection of KNT-127, 30 minutes prior to the test, significantly reduced immobility count, reflecting an antidepressant-like effect mediated by DOP stimulation. The mechanistic ...

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders.

Depression is common. In 2015, about 7 percent of the U.S. adult population—roughly 16 million adults—had at least one bout of depression in the last year, according to figures from the ...