Figure 1: Strategy for the identification of sense-antisense RNA duplexes. To test whether the described method was effective in enriching for endogenous antisense RNA, DNase I–treated total RNA from ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

The FANTOM Consortium for Genome Exploration Research Group, a large international collection of scientists that includes researchers at The Scripps Research Institute's Florida campus, is reporting ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

Dartmouth Medical School geneticists studying the biological clock have opened yet another window into the role of an unusual form of RNA known as antisense that blocks the messages of ...

In recent years, scientists have found that RNA--once thought to be little more than a bit player in the pathway from gene to protein--stands more center stage, playing a larger and more varied ...

Most scientists are fortunate if they can make one major discovery in their lifetime. Dr. Paul Zamecnik made two, each of which should have won him a Nobel Prize. Working with Dr. Mahlon Hoagland, he ...

HAMBURG and MARBURG, GERMANY / ACCESSWIRE / August 5, 2020 / Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) and the leading independent European antisense drug discovery ...

Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA.