Cryo-EM performance is fundamentally constrained not only by technical preparation challenges but also by intrinsic protein disorder, where dynamic and flexible regions remain unresolved despite ...

Nucleic acid extraction from biological samples is inherently difficult to execute consistently across different tissue types. Some tissue matrices are fibrous, contained in protective cell walls, or ...

In this interview, Pedro Machado shares expertise on electron microscopy, detailing sample preparation methods and the critical role of multimodal imaging in biological studies. Multimodal biological ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Histology is the branch of science that studies the structure and organization of cellular and noncellular components of tissues using a microscope. Within it, histopathology focuses on analyzing the ...

Observations at the nanoscale can provide profound insights into materials science. Yet, the characterization of beam-sensitive and reactive materials has proven challenging. In order to address this ...

Addressing interfacial effects during specimen preparation in cryogenic electron microscopy remains challenging. Here we introduce ESI-cryoPrep, a specimen preparation method based on electrospray ...

Sample preparation plays a crucial role in bioanalytical analysis involving chromatography. Insufficient sample preparation, such as skipping protein precipitation, phospholipid removal (PLR), ...

Although next-generation sequencing (NGS) keeps giving—exploring the human genome and revolutionizing our knowledge of health and disease—it needs to take a little, too. At the very least, NGS ...

Four principal methods govern the preparation of samples for XRF analysis, each representing a different trade-off between analytical quality and speed/cost of preparation. A method involving the ...