Researchers from the University of Copenhagen have mapped the structure of an important channel in human muscle cells. The new insights about the chloride channel can contribute to greater ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

Mutations in another kind of chloride channel, called the CFTR, are responsible for cystic fibrosis, the most common genetic disease in Caucasian populations. There are many varieties of ion channels.

A research team has discovered a previously unknown mechanism by which the immune system fights bacterial infections. The scientists found that a specific protein, the chloride channel PACC1, is ...

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems. Special channels in the cell membrane selectively permit salt ions to flow in and out ...

Scientists have generated structural images of a newly-described class of ion channels that help maintain the balance of pH inside brain cells. These molecular gates, called proton-activated chloride ...

Chloride channels constitute a widespread family of transmembrane proteins that mediate the selective passage of Cl− ions across cellular membranes. In mammals the CLC family comprises both ...

Laboratory cell experiments and computer simulations have revealed molecular mechanisms regulating a protein channel responsible for transporting chloride and other charged molecules across cell ...

Calcium-activated chloride channels (CaCCs) constitute a versatile class of membrane proteins that couple intracellular calcium signals to transmembrane chloride flux. Predominantly represented by the ...

When the adrenal gland produces too much aldosterone, this often leads to high blood pressure and kidney damage (hyperaldosteronism). It has only recently emerged that several patients harbor a ...

Since the discovery of the chloride ion channel ASOR three years ago, researchers have been searching for its biological functions. Now, the team led by Prof. Thomas Jentsch at the FMP and MDC in ...