Calcium-activated chloride channels (CaCCs) constitute a versatile class of membrane proteins that couple intracellular calcium signals to transmembrane chloride flux. Predominantly represented by the ...

Chloride channels constitute a widespread family of transmembrane proteins that mediate the selective passage of Cl− ions across cellular membranes. In mammals the CLC family comprises both ...

A research team has discovered a previously unknown mechanism by which the immune system fights bacterial infections. The scientists found that a specific protein, the chloride channel PACC1, is ...

Immunostaining (in green) for the Ca 2+ activated chloride channel TMEM16B on patient derived glioma stem cells. The blue color identifies nuclei. Chloride ion flows that enter the cells play an ...

Scientists identified a previously unknown chloride ion channel, which they named alkaliphile (Alka), as a taste receptor for alkaline pH. The sense of taste is among the first to come into contact ...

Credit: Shutterstock. NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel. The Food and Drug Administration (FDA) has granted Orphan Drug ...