Processive DNA polymerases that replicate chromosomes interact with a ring-shaped clamp that encircles DNA and slides along the duplex. All sliding clamps (Escherichia coli β-clamp, T4 bacteriophage ...

An elusive step in the process of human DNA replication has been observed, for the first time, by scientists. The step, which is crucial for DNA replication in humans and other forms of life, had ...

An elusive step in the process of human DNA replication has been observed for the first time, report scientists at Penn State University. The scientists say they’ve discovered how a key step in human ...

Another surprise was that the 9-1-1 clamp loader complex was observed to bind DNA in the opposite orientation from other clamp loader complexes that act on undamaged DNA during normal DNA replication.

According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human ...

For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh ...