In a recent study posted to the bioRxiv* pre-print server, researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) ...

Complement activation by antibodies bound to pathogens, tumors, and self antigens is a critical feature of natural immune defense, a number of disease processes, and immunotherapies. How antibodies ...

Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

The complement cascade evolved as a primitive surveillance system against pathogens 1. Some of the complement components have distinct antimicrobial activity. The fragments derived from C3 degradation ...

Specificity of serum complement component to elicit immunological demyelination. Rats received intraspinal infusions of demyelinating reagents, delivered by osmotic minipump, for a 7-day infusion at 0 ...

Circulating cold-insoluble complexes, observed in 11 of 31 patients with systemic lupus erythematosus (SLE), consisted mainly of immunoglobulin G and the C′lq component of complement and did not ...

This story was updated on February 5, 2019. Just when you thought ApoE biology couldn’t get any more complicated, scientists have discovered a new function for this apolipoprotein. According to a ...

In view of the importance of complement system in the initiation, regulation and end effects of immune responses and understanding of immune system as one of the targets for the toxic effects of ...