Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...

A new experimental procedure developed by researchers at Yale School of Medicine could help scientists better understand how DNA structure influences disease and development.

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be constantly folded and packaged. When it is time for cell division, and the ...

Our DNA is constantly being packed and unpacked. And there is a good reason for this: depending on its packing state, it performs different functions in the cell nucleus. For most of its life – this ...

Max Planck Institute of Molecular PhysiologyJul 10 2025 Reviewed If measured from beginning to end, the DNA in our cells is too long to fit into the cell’s nucleus, explaining why it must be ...

Every time a cell divides, it must accurately copy and distribute its DNA between two new cells. However, in some cases, chromosomes do not fully separate, leaving behind thin strands of DNA known as ...

During cell division, a safety mechanism called the NoCut checkpoint helps delay the final stages of division when DNA bridges are present. The researchers found that this delay allows ESCRT-III ...

Watson and Crick's discovery of DNA structure in 1953 revealed a possible mechanism for DNA replication. So why didn't ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...