Role for Drug Transporters Beyond Tumor Resistance: Hepatic Functional Imaging and Genotyping of Multidrug Resistance Transporters for the Prediction of Irinotecan Toxicity The marked variability of ...
A certain level of drug in blood is required for the benefit of medication. Low level of drug in blood may make the drug ineffective, while too high level may be toxic.
Drugs are used to prevent, alleviate and treat a variety of illnesses, ranging from the common flu to acute infection to chronic diseases like arthritis. Although the expenditure for drug development ...
Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...
Age, new comorbidities, inflammation, cognitive reserve, and changes in anxiety levels alter drug effects and recovery.
To develop a population pharmacokinetics model of oxcarbazepine in Chinese pediatric patients with epilepsy, and to study the interactions between oxcarbazepine and other antiepileptic drugs (AEDs). A ...
In a study posted to the bioRxiv* preprint server, researchers studied the preclinical pharmacokinetics (PK) and in vitro absorption, distribution, metabolism, and elimination (ADME) properties of ...
Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...
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