Big dog means big personality, right? That's true for Samson, a great Dane and Mastiff mix who certainly let his mom know ...

Puppies are already irresistible, but combining two stunning breeds results in a litter that's beyond adorable. In a TikTok video uploaded by Slove126 (@slove126) a precious posse of Great ...

No reason to call in Mystery Inc.: Landon will have you shouting "Scooby-Dooby-Doo!" when you see him at Heartland Small ...

Sean Casey Animal Recue implores people not to be deterred by Blayne's large size as he's just "an oversized puppy." ...

Vinnie’s story: Vinnie is a calm, sociable boy with a quiet demeanor. He’s low maintenance and never demanding. He’s living with a foster mom now, but is ready for his forever home.

GRAND JUNCTION, Colo. (KJCT) - Tango is a four-year-old Great Dane mix who is up for adoption at the Roice-Hurst Humane Society. Although he’s a tall boy, Tango loves to pretend he’s a lap dog and ...

Teagan, a Great Dane mix, was rescued from a backyard in Cary after police received a report of animal abuse. Courtesy of Nicole Kincaid When Nicole Kincaid picked up a 6-month-old Great Dane mix from ...

An owner who assumed her enormous stray puppy was a Great Dane mix was left stunned when the dog's DNA test revealed a completely different heritage. The owner, who manages a boarding barn in a rural ...

Rufus’ story: Looking for a big, lovable pup to join your family? Meet Rufus, born on Oct.10. With his goofy personality and heart full of love, this adorable boy is a handsome, gentle giant. He has ...

A Great Dane—American pit bull mix was just moments away from being euthanized in New Mexico when his fate took an unexpected turn. Newsweek spoke with Whitney Burton, an Albuquerque police officer ...

SCITUATE − What's 450 pounds, has 16 legs and is black, white and gray? The new pack at Scituate Animal Shelter. The shelter is caring for four great Danes, including three that are ready for adoption ...