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Calcium-induced release identified as key driver of dangerous muscle disorders
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium ...
A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers ...
Researchers looked at whether or not it was necessary to stock dantrolene, a drug used to treat malignant hyperthermia, at facilities using succinylcholine alone instead of volatile anesthetics, ...
Malignant hyperthermia is a potential side effect or complication that may arise in patients who have received general anesthesia. This adverse event typically occurs during surgery and other invasive ...
A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and ...
Malignant hyperthermia (MH) is a life‐threatening pharmacogenetic disorder of skeletal muscle characterised by a hypermetabolic response to certain anaesthetic agents. Research in this field has ...
A marketing authorization should be given for orphan medicine Agilus (dantrolene sodium, hemiheptahydrate) for the treatment of malignant hyperthermia, the European Medicines Agency (EMA) has said.
The US Food and Drug Administration (FDA) has approved an injectable form of dantrolene sodium (Ryanodex, Eagle Pharmaceuticals) for rapid treatment of malignant hyperthermia (MH), along with the ...
LINCOLNSHIRE, Ill.--(BUSINESS WIRE)--Nexus Pharmaceuticals announced the launch of Succinylcholine Chloride Injection, USP in 200mg/10mL Multiple-Dose Vials. It is an AP-rated generic to QUELICIN™ ¥. ...
A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and ...
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