A component of the immune system, called the immunoproteasome, is known to be involved in the adaptive immune system, but its role in the innate immune system is still a mystery. What scientists do ...

A newly published review article highlights the emerging importance of the immunoproteasome in the development and progression of diabetes and its wide-ranging complications, offering fresh ...

A newly published review article highlights the emerging importance of the immunoproteasome in the development and ...

Meet the masters of escape — cancers and many viruses that are adept at avoiding destruction by the body’s immune system. Understanding the immunoproteasome — expressed during cell stress — may be the ...

The alternative text for this image may have been generated using AI. Kirk, Groettrup and colleagues describe a new small-molecule inhibitor that selectively blocks immunoproteasome activity and ...

Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and ...

In a second patient who relapsed, the authors were able to confirm this dependency on the immunoproteasome by confirming the T TCR-4 therapy only reduced WT1+ AML cells that also co-expressed PSMB9, ...

The scientific campaign for a better version of Velcade (bortezomib, Takeda Oncology Co.) for multiple myeloma (MM) that began at Proteolix Inc. survived two mergers and ultimately failed, but led to ...

Scientists have observed that the immunoproteasome inhibits the repair function of alveolar macrophages. This opens up new therapeutic options. A specific inhibition of the immunoproteasome may ...

Scientists of Helmholtz Zentrum München, a partner in the German Center for Lung Research, have observed that the immunoproteasome inhibits the repair function of alveolar macrophages. This opens up ...