It's the ugly duckling story of the molecular world. Intein, thought two decades ago to be nothing more than a molecular parasite or a harmless hitchhiker, is today an invaluable tool in the ...

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with self-splicing protein domains called inteins.

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question. Proteins are the ...

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with laboratory-evolved self-splicing protein domains ...

The SCN1A gene is too large to fit into aconventional viral delivery systems. Scientists overcame this hurdle with a pioneering "split-intein" mechanism, which is like two separate trucks, delivering ...

At the recently concluded ARVO meeting, Splicebio S.L. presented the first preclinical results on the company’s new candidate, SB-007, for the treatment of Stargardt disease, a rare genetic disease ...

The ability to site-selectively incorporate a synthetic moiety like a biophysical probe, an unnatural amino acid, or a defined posttranslational modification into a protein of interest opens up a ...

Long-standing problem solved: Researchers discover that misfolding prevents efficient utilisation of so-called split inteins as ‘protein glue’ Proteins are the building blocks of life. They consist of ...