The first FRET sensor for distinguishing one-head-bound from two-head-bound states is a kinesin heterodimer in which one polypeptide chain contains a single cysteine residue in the plus-end-oriented ...

Biophysicists at Stanford University have finally answered one of the most fundamental questions in molecular biology: How does the tiny motor molecule, known as kinesin, move across a living cell?

Two-legged protein motors are currently marching around your cells delivering cargoes to precise locations, and with impeccable timing. These motors are transporting energy-producing mitochondria to ...

Dimers of the molecular motor kinesin can ‘walk’ along microtubules. A flexible neck connects the head of one kinesin of the dimer to its partner. When one head is bound to a microtubule, and when ...

Inside mammalian cells, kinesin plays the same role as do trucks and locomotives within our countries: it is the main driving force behind the transport of manufactured goods. No wheels are involved, ...

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...

This is a preview. Log in through your library . Abstract Kinesin I can walk on a microtubule for distances as long as several micrometers. However, it is still unclear how this molecular motor can ...