We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

However, the utility of linear (mixed) models in the context of meta-analysis of GWAS of binary phenotypes has not been previously explored.

Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability ...

Peter D. Hoff, Bilinear Mixed-Effects Models for Dyadic Data, Journal of the American Statistical Association, Vol. 100, No. 469 (Mar., 2005), pp. 286-295 ...