In a remarkable leap forward for synthetic biology, the AI model ESM3, developed by Evolutionary Scale, has achieved a significant milestone. By simulating half a billion years of evolutionary ...

The key insight with a new strategy for training protein engineering models, called EvoRank, is to harness the natural variations of millions of proteins generated by evolution over deep time and ...

Protein evolution plays a key role in many biological processes that are essential for life – but what does it have to do with physics? Schematic overview of procedure used to generate simulated ...

Schematic of the T7-ORACLE system. The genome is maintained by the non-mutagenic host replisome (gray), while an orthogonal T7 replisome (red) maintains only a dedicated plasmid (OR) at 100,000-fold ...

Researchers at Scripps have created T7-ORACLE, a powerful new tool that speeds up evolution, allowing scientists to design and improve proteins thousands of times faster than nature. Using engineered ...

Guided by a multimodal generative language model called ESM3, Thomas Hayes and colleagues generated and synthesized a previously unknown bright fluorescent protein, with a genetic sequence so ...

A Seoul National University research team has developed an ultra-fast analysis technology capable of tracking the protein ...