In an intricate dance, missteps or errant gestures between two partners can disturb the entire ensemble. Such is the molecular dance that is life. Here, the partners that need to hit their cues, ...

Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...

Scientists have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication. The computational tool is ...

Researchers have developed a type of peptides that can enter cells and block protein interactions considered difficult to ...

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because typical "small-molecule" drugs often prove to be too ...

Protein-Protein Interactions (PPIs) are critical for biological systems to function properly. Strong interactions maintain structural integrity and function, whereas weaker interactions enable ...

Scientists have used deep learning to design new proteins that bind to complexes involving other small molecules like hormones or drugs, opening up a world of possibilities in the computational design ...

A new method screens large libraries of synthetic cyclic peptides to identify compounds that can enter cells for therapeutic effect.

In the human body, the boundary between health and severe illness can be microscopic. For decades, molecular scientists have grappled with a frustrating biological reality: The proteins driving ...

Scientists from Cleveland Clinic and Cornell University have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat ...