In this review, the authors consider the characteristics and challenges of noninferiority trial designs, including seven essential features of noninferiority trials.

Causal models with design offer a systematic and unifying view to scientific inference and increase the clarity and speed of communication. Examples on the causal models for a case–control study, a ...

Active-comparator designs and new-user designs can help mitigate such biases in observational studies and improve the validity of their findings by making them more closely approximate RCTs.

Developing treatments for rare diseases poses many unique challenges that cannot be addressed by traditional study designs.

Prospective study designs can avoid the errors of case-control studies, but require large sample sizes. Family-based studies are also useful in overcoming errors due to population stratification.

3 Basic study design principles Concepts In all aspects of conducting a study we are trying to ensure we can make valid inference. In this sense much of application of statistics is concerned with ...

Invivyd (IVVD) announced that the SPEAR Study Group has issued their consensus recommendation for a clinical study design to evaluate the effects ...

The paper is concerned with problems of research methodology in organization studies. It places the main emphasis on the "research design," which is seen as an important tool for the planning, the ...

Twitter, Bias, and Trial Tweaks: ISCHEMIA Invites Debate on Study Designs and Endpoint Combos A special session at last week’s TCT meeting tackled the question of how best to design clinical trials in ...