This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

As animals and people age, there are changes in the genome. Telomeres, the protective ends of chromosomes, get shorter as cells continue to divide; some cells will pick up mutations in their genomes ...

The human genome contains approximately 1,600 types of transcription factors responsible for regulating gene activity across more than 400 tissue and cell types. Chromatin immunoprecipitation ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human genome, together with protein-coding sequences,” said Donate Weghorn, a ...

XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...

A particularly slippery transcription factor, MYCN, is thought to stimulate tumor cell growth and proliferation through amplification of gene transcription. MYCN and like proteins are slippery in the ...

Management of mitochondrial-related heart disease relies on multidisciplinary care and symptom control, as targeted gene-editing therapies are limited.

Baylor College of Medicine researchers report that they found the mechanism by which normal brain cells regulate the expression of the NFIA, or nuclear factor IA, gene, which is critical for both ...