Covalent inhibitors are a specialized class of small molecules designed to form chemical bonds with their target proteins, often resulting in prolonged target engagement and enhanced potency. The ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

The discovery of a stable single-electron covalent bond between two carbon atoms validates a century-old theory. The discovery of a stable single-electron covalent bond between two carbon atoms ...

A research team from Hokkaido University has confirmed a century-old theory by discovering a stable single-electron covalent bond, known as a sigma bond, between two carbon atoms. This unique bond ...

Chemists at Hokkaido University have experimentally confirmed the existence of a single-electron carbon-carbon bond for the first time (Nature 2024, DOI: 10.1038/s41586-024-07965-1). Linus Pauling ...