Metabolic acidosis is characterized by a primary reduction in serum bicarbonate (HCO 3 −) concentration, a secondary decrease in the arterial partial pressure of carbon dioxide (PaCO 2) of ∼1 mmHg for ...

Purpose: A rare adverse effect observed after dose escalation of topiramate therapy is discussed. A review of published cases, monitoring recommendations, and important counseling information for ...

The anion gap (AG) is an established biochemical marker that aids clinicians in the diagnosis and prognosis of acid–base disorders. In the context of critically ill patients, elevated AG values – ...

Describes acid-base physiology and discusses the diagnosis and treatment of disorders associated with metabolic acidosis and metabolic alkalosis, as well as plasma potassium disorders. Metabolic ...

The case: A 65-year-old man was found in a state of clouded consciousness of unknown duration. At hospital his Glasgow Coma Scale score was 9. Naloxone and thiamine were administered. A CT head scan ...

In his excellent discussion of Case 8-2001 (March 15 issue), 1 Dr. Wong did not mention that the low anion gap is another helpful clinical clue. On the day of admission, the patient had a relatively ...

Poisonings by the toxic alcohols (methanol, ethylene glycol, isopropanol, diethylene glycol, and propylene glycol) can cause cellular dysfunction and death, 1 but symptoms may be nonspecific. Delays ...

Although the teaching case report in the March 27 issue on a negative anion gap and elevated osmolar gap resulting from lithium overdose1 is interesting, I identified the following concern. In the ...

Clinical Advisor, a trusted source of medical news and feature content for healthcare providers, offers clinicians insight into the latest research to inform clinical practice and improve patient ...

Symptoms initially pointed to toxic alcohol ingestion. A recent case study published in Cureus detailed a dramatic presentation of acute multiple myeloma in a patient with acute kidney failure. The ...