Ironwood Pharma has issued an upbeat assessment of phase 3 trial data with apraglutide for short bowel syndrome (SBS), but missed secondary outcome measures led to a sharp decline in its share price.

The world “is the sum of its parts and the parts are all local,” wrote the Cumbrian painter Sheila Fell (1931–79) in 1961.

For a guy that only wears dirt-cheap Wranglers, I do spend a lot of time thinking about jeans. I've written big long stories about it over at Esquire Premium. I've bored my wife to tears digging ...