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In psychiatry, caregivers try to get free and informed consent of patients, but often feel required to restrict freedom and to use coercion. The present article develops ethical advice given by an ...

One objection to xenotransplantation is that it will require the large-scale breeding, raising and killing of genetically modified pigs. The pigs will need to be raised in designated pathogen-free ...

The development of the fifth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders—the DSM-5—has reenergised and driven further forward critical ...

Correspondence to Professor Charles Foster, Faculty of Law, University of Oxford, Oxford OX1 3UL,UK; Charles.Foster{at}gtc.ox.ac.uk Over the last quarter of a century, English medical law has taken an ...

Correspondence to Dr Joseph E Andrews, Institutional Review Board, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; jandrews{at}wakehealth.edu Cluster randomised clinical ...

The development of cancer therapies is a long and arduous process. Because it can take several years for a cancer agent to pass clinical testing and be approved for use, terminal cancer patients ...

Background Payment of healthy volunteers in medical research is a prevalent practice but is the subject of ethical debate. Although regulations to protect healthy volunteers exist, these regulations ...

The amended Terminally Ill Adults (End of Life) Bill (published 28 March 2025) proposes a new law allowing assisted dying in England and Wales. It acknowledges the need for safeguards to ensure that ...

Breastfeeding advocates have criticised the phrase ‘breast is best’ as mistakenly representing breastfeeding as a departure from the norm rather than the default for infant feeding. Breastfeeding ...

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Design of clinical trials for germline gene editing stretches current accepted standards for human subjects research. Among the challenges involved is a set of issues concerning intergenerational ...