Rutgers University12h
Scientists Discover Immune Cell Networks Driving Deadly Lung Disease
The study in the European Respiratory Journal used advanced spatial mapping techniques to compare healthy lung tissues and ...
A protective immune system cell disappears from a key form of fat, but only in those who are obese
The mammalian immune system is an evolutionary wonder. It's capable of recognizing and destroying cancer cells, and it can ...
BMJ22d
POS1238 FIRST EVIDENCE FOR EFFICACY OF CAR-T CELL TREATMENT IN REFRACTORY ANTISYNTHETASE SYNDROME
Whether other forms of severe autoimmune disease are sensitive to treatment with CD19 CAR-T cells has been unknown to date. Antisynthetase syndrome (ASS) is a autoimmune disease that affects muscles, ...
Frontiers24d
Case Report: Clinical and Serological Hallmarks of Cytokine Release Syndrome in a Canine B Cell Lymphoma Patient Treated With Autologous CAR-T Cells
Background: Chimeric antigen receptor-T (CAR-T) cells have transformed the treatment of human B cell malignancies. With the advent of CAR-T therapy, specific and in some cases severe toxicities have ...
Paul Tan29d
Honda reveals next-gen hydrogen fuel cell module – 50% lower production cost than previous model
According to Honda, development of the new hydrogen fuel cell module is being done completely in-house, unlike the current model that was jointly developed with General Motors (GM) and is ...
FierceBiotech29d
AI Сloud for Life Sciences. New Single Cell Foundational Model Use Case
The single-cell model developed by Converge Bio, in collaboration with Nebius, addresses this gap by creating a foundational model that can identify patient-level patterns while fully leveraging ...
lagradaonline1mon
Say goodbye to Down syndrome – this is the gene-editing technology that changes everything
Researchers are exploring gene editing as a cellular solution to trisomy. In Down syndrome cell lines, researchers were able to use CRISPR-Cas9 to eliminate excess copies of chromosome 21, allowing ...
EurekAlert!1mon
New AI model measures how fast the brain ages
Some common measures of biological age use blood samples to measure epigenetic aging and DNA methylation, which influences the roles of genes in the cell ... s disease patients, the new model ...
Medscape1mon
Rett Syndrome: Model of Neurodevelopmental Disorders
However, as we have learned more about this unique disorder, we have come to recognize Rett syndrome as a model of neurodevelopmental disorders. In the following sections, we describe the basis ...
Frontiers3y
Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells
Here, human induced pluripotent stem cell (iPSC) technology has emerged to provide a suitable patient-specific model system by recapitulating major characteristics of the disease in vitro, as well as ...
eLife4y
Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome
Down syndrome (DS) results in various ... In the prefrontal cortex of Ts65Dn mice (a well-established DS model), we found that the dendritic synaptic inhibitory loop formed by somatostatin-positive ...