CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and …

Nov 13, 2025 · Complete information for CD28 gene (Protein Coding), CD28 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human …

Figure 1. The CD28 receptor system. CD28 and CTLA-4 are stimulated by CD80 and CD86 ligands on activated APCs. Signals from CD28 are required for T cell activation and cytokine …

Jul 25, 2024 · In this Review, we explore recent insights into the molecular functions and regulation of CD28.

Nov 26, 2025 · The CD28 receptor on the T cell surface provides the co-stimulatory Signal 2, acting as the necessary “go” signal for activation. CD28 is constitutively expressed on most T …

Dec 15, 2023 · The receptors of the CD28 family interact with the B7 family of ligands. The cooperation between these molecules is essential for controlling the course of the adaptive …

In this paper, we mainly introduce the structure of CD28 and its related biological functions, as well as the application of costimulatory pathways targeting CD28 in disease treatment.

Jun 10, 2025 · CD28 is a pivotal costimulatory molecule that plays a crucial role in T cell activation. Understanding CD28 is essential for grasping the intricacies of immunology and its …

CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that acts as a co-stimulator, essential for T cell activation and survival. When CD28 is stimulated alongside the T-cell …